Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension

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• 作者：Haiyan Zhao^a ; Yunxin Xue^b ; Yun Guo^a ; Yue Sun^a ; Dongmei Liu^a ; Xiaofei Wang^a ; ^{xiaofei.wang@cstar.org.cn}
• 关键词：Endocan ; Pulmonary arterial hypertension ; Endothelial cells ; TNF-α ; MAPK
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：115-121
• 全文大小：1203 K
• 卷排序：42

文摘

Endocan is increased in the serum and lung of MCT-induced PAH rats. Endocan knockdown significantly improves right ventricular systolic pressure in MCT-induced PAH rats. Endocan knockdown inhibits the permeability increase and adhesion molecules secretion in RPMECs induced by TNF-α in vitro. Endocan knockdown inhibits the MAPK activation induced by TNF-α in vitro.