CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy

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• 作者：Rui Qin¹ ; ⁴ ; Shuai Cao¹ ; ⁴ ; Tianjie Lyu¹ ; Cai Qi¹ ; Weiguang Zhang² ; Yun Wang¹ ; ³ ; ⁵ ; ^{wangy66@bjmu.edu.cn}
• 关键词：CDYL ; neuronal migration ; transcription ; RhoA ; epilepsy
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：380-390
• 全文大小：4151 K
• 卷排序：18

文摘

The transcriptional corepressor CDYL drives neuronal migration in the brain CDYL regulates the actin cytoskeleton by transcriptionally repressing RhoA CDYL knockdown increases the excitability of cortical pyramidal neurons CDYL deficiency specifically increases the susceptibility to epilepsy