Integrative functional genomic analysis unveils the differing dysregulated metabolic processes across hepatocellular carcinoma stages

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Integrative functional genomic analysis unveils the differing dysregulated metabolic processes across hepatocellular carcinoma stages

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作者：Vignesh Ramesh ; Kumaresan Ganesan ; ^{kumar@oncocellomics.org" class="auth_mail" title="E-mail the corresponding author}
关键词：AFP ; alpha fetoprotein ; ALP ; alkaline phosphatase ; BCLC ; Barcelona-Clinic Liver Cancer ; CLIP ; Cancer of the Liver Italian Program ; DEN ; diethylnitrosamine ; GEO ; Gene Expression Omnibus ; HCC ; hepatocellular carcinoma ; HCV ; hepatitis C virus ; TCA ; tricarboxylic acid ; TCGA ; The Cancer Genome Atlas ; TNM ; tumor-node-metastasis ; WGCNA ; Weighted Gene Co-expression Network Analysis
刊名：Gene
出版年：2016
出版时间：15 August 2016
年：2016
卷：588
期：1
页码：19-29
全文大小：2317 K

文摘

•: Three metabolic process related gene-sets show deregulation in HCC transcriptome.
•: Fatty acid, inflammatory & nucleic acid metabolism are the three dysregulations.
•: These three metabolic gene-sets also represent the three HCC sub-types.
•: Deregulations in metabolic gene-sets are also found in HCC cells.

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