Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation

详细信息查看全文

作者：Anthony B. Mak¹ ; ² ; Mariana Pehar³ ; ¹ ; Allison M.L. Nixon¹ ; ² ; Rashida A. Williams¹ ; ² ; Andrea C. Uetrecht¹ ; ² ; Luigi Puglielli³ ; ⁴ ; Jason Moffat¹ ; ² ; ^{j.moffat@utoronto.ca" class="auth_mail}
关键词：CSC ; cancer stem cell ; ER ; endoplasmic reticulum ; ERGIC ; ER Golgi intermediate compartment ; IP-MS ; immunoprecipitation followed with tandem mass spectrometry ; MYTH ; membrane yeast two-hybrid ; shRNA ; short-hairpin RNA ; FACS ; fluorescent activated cell sorting ; BACE1 ; 尾-site APP cleaving enzyme 1
刊名：Journal of Molecular Biology
出版年：29 May 2014
年：2014
卷：426
期：11
页码：2175-2182
全文大小：1012 K

文摘

•: CD133 marks cancer progenitor cells and has a role in cancer progression.
•: ATase1/ATase2 regulates CD133 expression and trafficking by acetylating lysine residues positioned on the first extracellular loop of CD133.
•: ATase1/ATase2-mediated lysine acetylation is a form of CD133 protein regulation.
•: CD133 regulation and function can be targeted by inhibiting ATase1 or ATase2.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.