Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting

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Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting

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作者：Yiyin Chen^a ; Le Van Minh^a ; ^e ; Jianwen Liu^a ; Borislav Angelov^b ; Markus Drechsler^c ; Vasil M. Garamus^d ; Regine Willumeit-R&ouml ; mer^d ; Aihua Zou^a ; ^{aihuazou@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Baicalin ; Liposomes ; Folate receptor ; Cryo-TEM ; SAXS ; Targeting drug delivery
刊名：Colloids and Surfaces B: Biointerfaces
出版年：2016
出版时间：1 April 2016
年：2016
卷：140
期：Complete
页码：74-82
全文大小：1638 K

文摘

•: Stable baicalin-loaded folate-receptor-targeted liposomes were designed and prepared.
•: DLS, cryo-TEM and SAXS were used to study the physicochemical properties.
•: The drug loading of BAI in the liposomes was about 9.5%.
•: Baicalin loaded FR-targeted liposomes showed higher cytotoxicity and cell uptake compared with non-targeted liposomes.

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