WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth

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WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth

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作者：Ricardo Gargini¹ ; ² ; ³ ; ⁶ ; Maribel Escoll² ; ³ ; ⁶ ; Esther Garcí ; a¹ ; ³ ; Ramó ; n Garcí ; a-Escudero⁴ ; ⁵ ; Francisco Wandosell² ; ³ ; ^{fwandosell@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author} ; Iné ; s Marí ; a Antó ; n¹ ; ³ ; ⁷ ; ^{ianton@cnb.csic.es" class="auth_mail" title="E-mail the corresponding author}
关键词：WIPF1 ; YAP/TAZ ; glioma ; breast cancer ; tumor initiating cell ; proliferation ; actin dynamics ; Hippo pathway ; β-catenin destruction complex ; multivesicular body
刊名：Cell Reports
出版年：2016
出版时间：15 November 2016
年：2016
卷：17
期：8
页码：1962-1977
全文大小：6602 K

文摘

•: High WIP levels promote YAP/TAZ stability and correlate with poor patient survival
•: WIP regulates the endocytic/endosomal system via Rac/PAK and the formin mDia
•: WIP expression leads to sequestration of the β-catenin destruction complex in MVB
•: WIP reduction impairs in vivo glioblastoma growth, notably increasing mouse survival

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