Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders

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• 作者：Katherine O'Farrell<sup>asup> ; Andrew Harkin<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>aharkin@tcd.iesup>
• 关键词：Stress ; Inflammation ; Kynurenine pathway ; Neurodegenerative diseases ; Psychiatric disorders
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：307-323
• 全文大小：1008 K
• 卷排序：112

文摘

This review assesses recent advances in determining a role for the kynurenine pathway (KP) in neurological disorders. This review examines the efficacy, or lack thereof, of pharmacological modulators of the KP in neurological disorders. This review identifies the need for further research to clarify if targeting the KP is a worthy pursuit therapeutically.