The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks

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The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks

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作者：Moonjung Hyun^a ; ¹ ; Seoyun Choi^a ; Tinna Stevnsner^b ; Byungchan Ahn^a ; ^{bbccahn@mail.ulsan.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：CPT ; camptothecin ; DSB ; double-strand breaks ; HU ; hydroxyurea ; IR ; ionizing irradiation
刊名：Cellular Signalling
出版年：2016
出版时间：March 2016
年：2016
卷：28
期：3
页码：214-223
全文大小：1569 K

文摘

•: WRN-1 functions in the DNA damage checkpoint in response to CPT-induced DSB.
•: WRN-1 acts downstream of MRE-11 and RPA-1, but upstream of CHK-1.
•: WRN-1 is also involved in the repair of CPT-induced DSB.

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