Objective
To determine the e
fficac
y o
f the preimplantation c
ytogenetic anal
ysis o
f the embr
yos obtained
from patient with mosaic Turner s
yndrome be
fore an IVF program.
Design
Prospective cytogenetic analysis.
Setting
University-based tertiary medical center.
Patient(s)
A 29 year-old female, a partner in a couple with male factor infertility, was diagnosed with mosaic Turner syndrome with a 45,X [17]/46,XX [13] karyotype.
Intervention(s)
Preimplantation genetic diagnosis was performed on four blastomeres obtained from four different embryos by florescence in situ hybridization probes specific to chromosomes X, Y, 13, 18, 21 in an intracytoplasmic sperm injection cycle.
Main Outcome Measure(s)
Blastomeres with normal signals.
Result(s)
Two blastomeres detected as normal were transferred and pregnancy was achieved.
Conclusion(s)
Preimplantation Genetic Diagnose should be considered in the infertility treatment of the patient with mosaic Turner Syndrome.
