Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-α (TNF-α) and 8-iso-prostaglandin F_2α (8-iso-PGF_2α)

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• 作者：G. Topal^a ; ^{gokce_topal@hotmail.com} ; A. Donmez^b ; B.S. Uydes Doğ ; an^a ; M. Kucur^c ; D. Taspinar Cengiz^d ; F.B. Berkoz^b ; N. Erdogan^b
• 关键词：Fibromyalgia ; ADMA ; TNF-&#x3b1 ; IL-6 ; 8-iso-PGF_2&#x3b1 ;
• 刊名：Clinical Biochemistry
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：44
• 期：5-6
• 页码：364-367
• 全文大小：165 K

文摘

Objective

The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F_2α (8-iso-PGF_2α) in patients with fibromyalgia.

Design and method

Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF_2α levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results

Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF_2α were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF_2α levels in patients with fibromyalgia.

Conclusion

This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF_2α and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.