Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation

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Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation

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作者：Maria Isabel Castellanos^a ; ^b ; ^{maria.isabel.castellanos@upc.edu" class="auth_mail" title="E-mail the corresponding author} ; Carlos Mas-Moruno^a ; ^b ; ^{carles.mas.moruno@upc.edu" class="auth_mail" title="E-mail the corresponding author} ; Anna Grau^a ; ^b ; ^{agraugar@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Xavier Serra-Picamal^d ; ^e ; ^f ; ^{xserrapicamal@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Xavier Trepat^d ; ^e ; ^f ; ^{xtrepat@ub.edu" class="auth_mail" title="E-mail the corresponding author} ; Fernando Albericio^g ; ^{fernando.albericio@irbbarcelona.org" class="auth_mail" title="E-mail the corresponding author} ; Michael Joner^h ; ⁱ ; ^{michaeljoner@me.com" class="auth_mail" title="E-mail the corresponding author} ; Francisco Javier Gil^a ; ^b ; ^{francesc.xavier.gil@upc.edu" class="auth_mail" title="E-mail the corresponding author} ; Maria Pau Ginebra^a ; ^b ; ^d ; ^{maria.pau.ginebra@upc.edu" class="auth_mail" title="E-mail the corresponding author} ; Jose Marí ; a Manero^a ; ^b ; ^{jose.maria.manero@upc.edu" class="auth_mail" title="E-mail the corresponding author} ; Marta Pegueroles^a ; ^b ; ^{marta.pegueroles@upc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：CoCr alloy ; Surface functionalization ; Cell adhesive peptides ; HUVEC proliferation ; Endothelialization ; SMCs adhesion
刊名：Applied Surface Science
出版年：2017
出版时间：30 January 2017
年：2017
卷：393
期：Complete
页码：82-92
全文大小：2707 K

文摘

•: We immobilized peptides on CoCr alloy through physisorption and covalent bonding.
•: Surface activation is an essential step prior to silanization to enhance peptide attachment.
•: Biofunctionalized surface characteristics were discussed.
•: RGDS, YIGSR and combination peptides display an improved HUVECs adhesion and proliferation.