Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ

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• 作者：C. Herbert Pratt^a ; ^{Herbert.Pratt@jax.org} ; Christopher S. Potter^a ; Raoul V. Kuiper^b ; Son Yong Karst^a ; Soheil S. Dadras^c ; ^d ; Derry C. Roopenian^a ; John P. Sundberg^a
• 关键词：M. ; Mus ; M.m. ; Mus mus ; spp ; species ; MYA ; million years ago ; Xpr1 ; xenotropic and polytropic retrovirus receptor 1 ; XMRV ; Xenotropic murine leukemia virus-related virus ; Lamc2 ; laminin ; gamma 2 ; jeb ; junctional epidermolysis bullosa ; H&E ; hematoxylin and eosin ; VVG ; Verhoeff-Van Gieson ; Col17a1 ; collagen type XVII ; alpha 1
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：128-132
• 全文大小：1650 K
• 卷排序：102

文摘

Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases. The dermal collagen bundles were abnormally thickened and branched. Elastin fiber deposition was focally altered in the dermis adjacent to the hair follicle. Collagens present in the skin could not be differentiated between the species in protein gels following digestion with pepsin. Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.).