Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice

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Calcitriol inhibits bleomycin-induced early pulmonary inflammatory response and epithelial-mesenchymal transition in mice

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作者：Zhu-Xia Tan^a ; ¹ ; Yuan-Hua Chen^b ; ^c ; ¹ ; Shen Xu^a ; Hou-Ying Qin^a ; Cheng Zhang^b ; Hui Zhao^a ; ^{zhaohuichenxi@126.com" class="auth_mail" title="E-mail the corresponding author} ; De-Xiang Xu^b ; ^{xudex@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Calcitriol ; Bleomycin ; Inflammation ; Nuclear factor kappa B p65 ; Epithelial&ndash ; mesenchymal transition ; Lung ; Mice
刊名：Toxicology Letters
出版年：2016
出版时间：5 January 2016
年：2016
卷：240
期：1
页码：161-171
全文大小：4967 K

文摘

•: Calcitriol attenuates BLM-induced inflammatory cytokines in the lungs.
•: Calcitriol inhibits BLM-activated NF-κB signaling in the lungs.
•: Calcitriol inhibits BLM-activated PI3K/Akt and p38 MAPK in the lungs.
•: Calcitriol inhibits BLM-induced EMT in the lungs.
•: Calcitriol inhibits BLM-activated TGF-β-Smad signaling in the lungs.

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