Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice

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Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice

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作者：Yuan Dai^a ; ¹ ; ^{daniya5@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Tao Ma^b ; ¹ ; ^{matao327@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiangyi Ren^a ; ¹ ; ^{amideby@sina.cn" class="auth_mail" title="E-mail the corresponding author} ; Jiangping Wei^a ; ^{sichuanwjp@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wenjun Fu^a ; ^{fwj10330@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yuntong Ma^a ; ^{mayuntong06@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shijun Xu^a ; ^{docxu@126.com" class="auth_mail" title="E-mail the corresponding author} ; Zhanjun Zhang^c ; ^d ; ^{zhang_rzs@bnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Alzheimer&rsquo ; s disease ; Tongluo Xingnao Effervescent Tablet ; Mitochondria ; Energy metabolism
刊名：Neuroscience Letters
出版年：2016
出版时间：6 September 2016
年：2016
卷：630
期：Complete
页码：101-108
全文大小：1486 K

文摘

•: TXET, a traditional Chinese herbal formula, has been widely used for decades in China.
•: TXET can ameliorate cognitive dysfunction.
•: We investigated the effects of TXET on mitochondrial function and energy metabolism in APPswe/PS1De9 mice.
•: TXET increased the mitochondrial membrane potential, energy charge levels, activity of respiratory chain complexes and Na+-K+ ATPase activity in APPswe/PS1De9 mice.

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