G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling

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• 作者：Syamantak Majumder¹ ; ⁵ ; GuoFu Zhu² ; ⁵ ; Xiangbin Xu³ ; Sharon Senchanthisai¹ ; Dongyang Jiang² ; Hao Liu² ; Chao Xue¹ ; Xiaoqun Wang¹ ; Heidi Coia¹ ; Zhaoqiang Cui¹ ; Elaine M. Smolock¹ ; Richard T. Libby⁴ ; Bradford C. Berk¹ ; Jinjiang Pang¹ ; ² ; ⁶ ; ^{jinjiang_pang@urmc.rochester.edu}
• 关键词：Delta-like 4 ; G-protein-coupled receptor-2-interacting protein1 ; stalk cell fate
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2532-2541
• 全文大小：4500 K
• 卷排序：17

文摘

GIT1 is highly expressed in stalk cells but not in tip cells GIT1 inhibits the Dll4-Notch1 feedback loop by binding to RBP-J in stalk cells GIT1 competes with N1-ICD to bind to RBP-J through its ANK domain