PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis

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PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis

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作者：Min Chen^a ; Hong Wang^a ; Xiangdong Li^a ; Ning Li^a ; ^b ; Guoheng Xu^c ; Qingyong Meng^a ; ^b ; ^{qingyong.meng@gmail.com" class="auth_mail} ; ^{qymeng@cau.edu.cn" class="auth_mail}
关键词：P21 ; postnatal day 21 ; PAS ; periodic acid-Schiff ; Prm1 ; Protamine 1 ; Tnp2 ; transition protein 2 ; Wbp2nl ; WW Domain-Binding Protein 2-Like ; Fscn3 ; fascin homolog 3 ; LDs ; lipid droplets ; PKA ; protein kinase A ; HSL ; hormone-sensitive lipase ; BSA ; albumin from bovine serum ; CASA ; computer-aided sperm analysis ; PBS ; phosphate-buffered saline ; RT-PCR ; reverse transcription polymerase chain reaction ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; SD ; standard deviation ; SEM ; standard error ; H&E ; hema
刊名：Gene
出版年：15 June 2014
年：2014
卷：543
期：2
页码：212-219
全文大小：1039 K

文摘

•: Many meiosis-related genes were up-regulated in PLIN1 deficient mice at P21.
•: Increased ratio of seminiferous tubules with spermatids in PLIN1^−/− mice at P21
•: The fertility of PLIN1 knockout mice was similar to that of wild-type mice.

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