LSD1 sustains pancreatic cancer growth via maintaining HIF1伪-dependent glycolytic process

详细信息    查看全文

• 作者：Yi Qin^a ; ^b ; ^c ; ¹ ; Wenwei Zhu^a ; ^c ; ¹ ; Wenyan Xu^a ; ^c ; ¹ ; Bo Zhang^a ; ^b ; ^c ; Si Shi^a ; ^b ; ^c ; Shunrong Ji^a ; ^b ; ^c ; Jiang Liu^a ; ^b ; ^c ; Jiang Long^a ; ^b ; ^c ; Chen Liu^a ; ^b ; ^c ; Liang Liu^a ; ^b ; ^c ; Jin Xu^a ; ^c ; ^{xjuin@163.com" class="auth_mail} ; Xianjun Yu^a ; ^b ; ^c ; ^{yuxianjun88@hotmail.com" class="auth_mail}
• 关键词：LSD1 ; Pancreatic cancer ; Glycolysis ; HIF1伪
• 刊名：Cancer Letters
• 出版年：1 June, 2014
• 年：2014
• 卷：347
• 期：2
• 页码：225-232
• 全文大小：1953 K

文摘

The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients. Using in vitro and in vivo models, we demonstrated that knock-down of LSD1 repressed proliferation and tumorigenicity of pancreatic cancer cells. Mechanistically, our study demonstrated that LSD1 synergized with HIF1伪 (hypoxia inducible factor-1伪) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation.