Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring

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Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring

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作者：Ying Jiang¹ ; Wei Xia¹ ; Yingshuang Zhu ; Xiaocui Li ; Danqi Wang ; Juan Liu ; Huailong Chang ; Gengqi Li ; Bing Xu ; Xi Chen ; Yuanyuan Li ; ^{liyuanyuan@hust.edu.cn" class="auth_mail} ; Shunqing Xu ; ^{xust@hust.edu.cn" class="auth_mail}
关键词：ACOX1 ; peroxisomal acyl-coenzyme A oxidase 1 ; ALT ; alanine aminotransferase ; AST ; glutamic-oxalacetic transaminease ; BPA ; bisphenol A ; DGE ; differential gene expression ; FAO ; fatty acid oxidation ; FFAs ; free fatty acids ; GD ; gestational day ; MRC ; mitochondrial respiratory complex ; MMP ; mitochondrial membrane potential ; NAFLD ; nonalcoholic fatty liver disease ; PND ; postnatal day ; ROS ; reactive oxygen species ; TDI ; tolerable daily intake ; TG ; triglyceride ; UQCRC2 ; cytochrome b-c1 complex subunit 2
刊名：Toxicology Letters
出版年：15 July 2014
年：2014
卷：228
期：2
页码：85-92
全文大小：2789 K

文摘

•: Perinatal exposure to BPA induces hepatic steatosis in the offspring of wistar rats in adulthood.
•: Mitochondrial dysfunction is highly implicated in the early development of NALFD.
•: Hepatic mitochondrial dysfunction contributes to the consequent hepatic steatosis.

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