Identification and functional characterizations of serpin8, a potential prophenoloxidase-activating protease inhibitor in Pacific white shrimp, Litopenaeus vannamei

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• 作者：Yongjie Liu ; Yuhang Sun ; Qiai Wang ; Fujun Hou ; Xiaolin Liu ; ¹ ; ^{liuxiaolin@nwsuaf.edu.cn}
• 关键词：Litopenaeus vannamei ; Serpin8 ; dsRNA ; Proteases ; Prophenoloxidase system
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：492-501
• 全文大小：3184 K
• 卷排序：60

文摘

A novel serpin (named Lvserpin8) was identified from the Pacific white shrimp, Litopenaeus vannamei. Lvserpin8 had the highest expressional level in hepatopancreas and was significantly up-regulated upon bacterial infection. Suppression of Lvserpin8 increased the transcripts of LvPPAE2 and cumulative mortality. rLvserpin8 displayed inhibition roles on protease activity, and prophenoloxidase activation.