Zinc alpha2 glycoprotein alleviates palmitic acid-induced intracellular lipid accumulation in hepatocytes

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• 作者：Xinhua Xiao^a ; ¹ ; Han Li^a ; ¹ ; Xiaoyan Qi^a ; Yadi Wang^a ; Canxin Xu^b ; Gexin Liu^a ; Gebo Wen^a ; Jianghua Liu^a ; ^{jianghua990@163.com}
• 关键词：Non-alcoholic fatty liver disease ; Triglycerides ; Fatty acid oxidation ; Lipogenesis ; Nuclear receptors ; Adiponectin
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：155-164
• 全文大小：2279 K
• 卷排序：439

文摘

This paper provides the first physiological evidence for the role of Zinc alpha2 glycoprotein (ZAG) in the regulation of lipid metabolism in hepatocytes. Our study has identified, for the first time, manipulation of ZAG expression in hepatocytes altered hepatic TG accumulation and the expression of key fatty acid oxidation genes and lipogenesis genes. ZAG could also dramatically stimulate adiponectin expression in hepatocytes.