P21<sup>Waf1/Cip1</sup> plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation

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P21^Waf1/Cip1 plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation

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作者：Sijun Deng ; Shusheng Tang ; Chongshan Dai ; Yan Zhou ; Xiayun Yang ; Daowen Li ; Xilong Xiao ; ^{xiaoxl@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：p21 ; Furazolidone ; Apoptosis ; ROS ; Caspase activation
刊名：Food and Chemical Toxicology
出版年：2016
出版时间：February 2016
年：2016
卷：88
期：Complete
页码：1-12
全文大小：2738 K

文摘

•: FZD destabilized the p21 protein through suppressing PI3K/Akt pathway.
•: P21 inhibits FZD-induced caspase activation in HepG2 cells.
•: P21 modulates FZD-induced ROS generation in HepG2 cells.
•: p21 played an anti-apoptotic role in FZD-induced apoptosis in HepG2 cells.

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