FZD destabilized the p21 protein through suppressing PI3K/Akt pathway.
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P21 inhibits FZD-induced caspase activation in HepG2 cells.
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P21 modulates FZD-induced ROS generation in HepG2 cells.
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p21 played an anti-apoptotic role in FZD-induced apoptosis in HepG2 cells.
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