Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A<sup>DCAF1</sup> to promote colon cancer development

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Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A^DCAF1 to promote colon cancer development

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作者：Weiguo Ren^a ; ^b ; ^c ; Shourong Shen^a ; ^b ; Zhenqiang Sun^c ; Peng Shu^a ; Xiaohua Shen^a ; Chibin Bu^a ; Feiyan Ai^a ; ^b ; Xuemei Zhang^c ; Anliu Tang^a ; ^b ; Li Tian^a ; ^b ; Guiyuan Li^b ; ^c ; Xiayu Li^a ; ^b ; ^{lixiayu@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jian Ma^a ; ^b ; ^c ; ^{majian@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：DICER1 ; CUL4ADCAF1 ligase complex ; Jak-STAT3 ; Ubiquitination ; Colon cancer ; IL-6
刊名：Cancer Letters
出版年：2016
出版时间：1 June 2016
年：2016
卷：375
期：2
页码：209-220
全文大小：5096 K

文摘

•: Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by CUL4A^DCAF1.
•: DICER1 and p-STAT3 expression has close correlation in colon cancer.
•: Lower DICER1 expression in colon cancer correlates with poor survival.

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