Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction

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Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction

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作者：Daowen Li ; Chongshan Dai ; Yan Zhou ; Xiayun Yang ; Kena Zhao ; Xilong Xiao ; Shusheng Tang ; ^{tssfj@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Olaquindox ; GADD45a ; Apoptosis ; Mitochondrial dysfunction ; ROS
刊名：Environmental Toxicology and Pharmacology
出版年：2016
出版时间：September 2016
年：2016
卷：46
期：Complete
页码：140-146
全文大小：2114 K

文摘

•: The cytotoxic effect of olaquindox in HepG2 cells was investigated.
•: Olaquindox-induced apoptosis involved the GADD45a expression in HepG2 cells.
•: Knockdown of GADD45 enhanced olaquindox-induced cell death and apoptosis.
•: Knockdown of GADD45 enhanced olaquindox-induced mitochondrial dysfunction.

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