MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells

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MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells

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作者：Xinlu Liu^a ; ^b ; ¹ ; Fei Luo^a ; ^b ; ¹ ; Min Ling^c ; Lu Lu^a ; ^b ; Le Shi^a ; ^b ; Xiaolin Lu^a ; ^b ; Hui Xu^a ; ^b ; Chao Chen^a ; ^b ; Qianlei Yang^a ; ^b ; Junchao Xue^a ; ^b ; Jun Li^d ; Aihua Zhang^d ; Qizhan Liu^a ; ^b ; ^{drqzliu@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{drqzliu@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：miRNA-21 ; Gene of phosphate and tension homology deleted on chromosome ten (PTEN) ; Extracellular regulated protein kinase (ERK) ; Autophagy ; Arsenite
刊名：Toxicology Letters
出版年：2016
出版时间：11 June 2016
年：2016
卷：252
期：Complete
页码：1-10
全文大小：2575 K

文摘

•: Elevated levels of miR-21 are associated with arsenite-induced autophagy in L-02 cells.
•: miR-21-activated ERK signaling via inhibition of PTEN is involved in arsenite-induced autophagy in L-02 cells.
•: Autophagy regulated by miR-21 via PTEN/ERK signaling is involved in arsenite-induced carcinogenesis.

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