Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals

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• 作者：Yaling Wu¹ ; ² ; ⁴ ; Dingbin Tang² ; ³ ; ⁴ ; Na Liu¹ ; ² ; Wei Xiong² ; Huanwei Huang² ; Yang Li² ; Zhixiong Ma¹ ; ² ; Haijiao Zhao² ; Peihao Chen² ; Xiangbing Qi² ; Eric Erquan Zhang² ; ⁵ ; ^{zhangerquan@nibs.ac.cn}
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：73-85
• 全文大小：7054 K
• 卷排序：25

文摘

The hypoxic response is gated by the circadian clock in vivo HIF1A is the regulatory node that connects hypoxia signaling with the circadian clock ChIP-seq analyses demonstrated that HIF1A and BMAL1 engage in synergistic crosstalk A heart attack model emphasizes the pathological significance of this crosstalk