Ni-catalyzed cross-coupling reaction of aryl chlorides with arylboronic acids in IPA without using a reducing reagent

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• 作者：Li Zhou ; Qingqing Miao ; Ren He ; Xiujuan Feng ; Ming Bao
• 关键词：Nickel catalyst ; Suzuki coupling ; Aryl chloride ; Isopropanol
• 刊名：Tetrahedron Letters
• 出版年：2007
• 出版时间：29 October 2007
• 年：2007
• 卷：48
• 期：44
• 页码：7899-7902
• 全文大小：211 K

文摘

The coupling reaction of aryl chlorides with arylboronic acids was successfully performed in isopropanol (IPA) by using [NiCl(Ph₂PCH₂CH₂OH)₂(H₂O)]Cl (5), a cationic Ni(II)-complex, as a precatalyst in the absence of a reducing agent. The coupling reaction proceeded smoothly under mild conditions to provide biaryls in satisfactory to excellent yields, and formation of the undesired dechlorination products of aryl chlorides was completely prevented.