Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1

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Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1

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作者：Dan Li ; Tingting Song ; Lin Yang ; ^{lin_yang2002@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xueying Wang ; Changhong Yang ; Yongsheng Jiang
关键词：CAT ; catalase ; CRT ; cylinder rearing test ; GPx ; glutathione peroxidase ; GST ; glutathione S-transferase ; HI ; hypoxic&ndash ; ischemic ; HO-1 ; heme oxygenase-1 ; IL-1 ; βiInterleukin-1β ; IR ; ischemia/reperfusion ; NOR ; novel object recognition ; PTE ; pterostilbene ; ROS ; reactive oxygen species ; SOD ; superoxide dismutase ; TBARS ; thiobarbituric acid reactive substances ; TNFα ; tumor necrosis factor α ; ZnPP ; zinc protoporphyrin IX
刊名：International Journal of Developmental Neuroscience
出版年：2016
出版时间：November 2016
年：2016
卷：54
期：Complete
页码：22-31
全文大小：1808 K

文摘

•: PTE exhibited excellent neuroprotective effects against neonatal HI brain injury.
•: PTE pretreatment inhibited inflammation and programmed cell death.
•: PTE pretreatment decreased oxidative stress.
•: ZnPP inhibited PTE-induced suppression of oxidative stress, programmed cell death.
•: ZnPP inhibited PTE-induced suppression of inflammation and brain damage.

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