Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson’s disease

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• 作者：Mingming Zhang^a ; ^&dagger ; ; Hongbo Mu^b ; ^&dagger ; ; Zhenwei Shang^a ; ^&dagger ; ; Kai Kang^c ; ^&dagger ; ; Hongchao Lv^a ; Lian Duan^a ; Jin Li^a ; Xinren Chen^a ; Yanbo Teng^a ; Yongshuai Jiang^a ; ^{jiangyongshuai@gmail.com} ; Ruijie Zhang^a ; ^{zhangruijie_2015@163.com}
• 关键词：AD ; Alzheimer&rsquo ; s disease ; CAMs ; cell adhesion molecules ; dbGaP ; Genotypes and Phenotypes ; ECM ; extra cellular matrix ; FAK ; focal adhesion kinase ; FAs ; focal adhesions ; FDR ; false discovery rate ; GWAS ; genome-wide association study ; HLA ; Human Leucocyte Antigen ; HWE ; Hardy&ndash ; Weinberg equilibrium ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; LD ; Linkage disequilibrium ; NINDS ; National Institute of Neurological Disorders and Stroke ; PD ; Parkinson&rsquo ; s disease ; RA ; rheumatoid arthritis
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：398-410
• 全文大小：687 K
• 卷排序：340

文摘

We performed pathway analysis based on the moderate genes. Among our results, there are four pathways to be reported in previous studies. Our findings implied that there was an association between immune response and PD.