Letrozole regulates actin cytoskeleton polymerization dynamics in a SRC-1 dependent manner in the hippocampus of mice

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• 作者：Yangang Zhao^a ; ¹ ; Yanlan Yu^b ; ¹ ; Yuanyuan Zhang^a ; Li He^c ; Linli Qiu^c ; ^d ; Jikai Zhao^a ; Mengying Liu^a ; Jiqiang Zhang^a ; ^{zhangjqtmmu@yahoo.com}
• 关键词：Hippocampus ; Estrogens ; Aromatase ; Letrozole ; Steroid receptor coactivator-1 ; Actin cytoskeleton
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：86-97
• 全文大小：4148 K
• 卷排序：167

文摘

Hippocampal aromatase and actin polymerization are developmentally regulated. Letrozole inhibits hippocampal actin polymerization in vivo and in vitro. Estradiol rescue LET induced downregulation of actin remodeling proteins. SRC-1 knockdown suppresses E2 induced increased of actin remodeling proteins. Hippocampal E2 regulates actin polymerization in a SRC-1 dependent manner.