Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKC<sub>α</sub> and PKC<sub>β2</sub> inhibition

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Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKC_α and PKC_β2 inhibition

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作者：Yupeng Hu ; Xufeng Tao ; Xu Han ; Lina Xu ; Lianhong Yin ; Yan Qi ; Yanyan Zhao ; Youwei Xu ; Changyuan Wang ; Jinyong Peng ; ^{jinyongpeng2008@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Anti-oxidative stress ; Dioscin ; Gastric ischemia-reperfusion ; Natural product ; PKC/ERK1/2 signaling pathway
刊名：Chemico-Biological Interactions
出版年：2016
出版时间：25 October 2016
年：2016
卷：258
期：Complete
页码：234-244
全文大小：5455 K

文摘

•: Dioscin significantly protected GES-1 cells against I/R injury.
•: Dioscin significantly attenuated gastric I/R injury in rats.
•: Dioscin attenuated oxidative stress and inflammatory response.
•: Dioscin adjusted PKC/ERK1/2 pathway via PKC_α and PKC_β2 inhibition.

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