Effects of 16-month treatment with the cathepsin K inhibitor ONO-5334 on bone markers, mineral density, strength and histomorphometry in ovariectomized cynomolgus monkeys

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Effects of 16-month treatment with the cathepsin K inhibitor ONO-5334 on bone markers, mineral density, strength and histomorphometry in ovariectomized cynomolgus monkeys

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作者：Hiroyuki Yamada^a ; ^{hi.yamada@ono.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasuo Ochi^a ; Hiroshi Mori^a ; Satoshi Nishikawa^a ; Yasuaki Hashimoto^a ; Yasutomo Nakanishi^a ; Makoto Tanaka^a ; Mark Bruce^b ; Steve Deacon^b ; Kazuhito Kawabata^a
关键词：ONO-5334 ; Osteoporosis ; Cathepsin K inhibitor ; Ovariectomized cynomolgus monkeys
刊名：Bone
出版年：2016
出版时间：May 2016
年：2016
卷：86
期：Complete
页码：43-52
全文大小：1046 K

文摘

•: ONO-5334 was evaluated in an ovariectomized cynomolgus monkey osteoporosis model.
•: ONO-5334 decreased bone resorption markers below the Sham level, while keeping bone formation markers above the Sham level.
•: ONO-5334 increased vertebral and non-vertebral bone mineral density.
•: ONO-5334 affected cortical bone mass and geometry.
•: ONO-5334 increased bone strength in the lumbar vertebral body.

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