Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys

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Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys

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作者：Yasuo Ochi ; ^{y.ochi@ono.co.jp" class="auth_mail} ; Hiroyuki Yamada ; Hiroshi Mori ; Yasutomo Nakanishi ; Satoshi Nishikawa ; Ryoji Kayasuga ; Naoki Kawada ; Akiko Kunishige ; Yasuaki Hashimoto ; Makoto Tanaka ; Masafumi Sugitani ; Kazuhito Kawabata
关键词：CATHEPSIN K ; ONO-5334 ; Bone mineral density ; Bone metabolism ; Bone strength
刊名：Bone
出版年：August 2014
年：2014
卷：65
期：Complete
页码：1-8
全文大小：577 K

文摘

•: ONO-5334 decreased bone resorption in ovariectomized (OVX) monkeys.
•: ONO-5334 spared bone formation in OVX monkeys.
•: ONO-5334 increased both vertebral and non-vertebral bone mineral densities (BMD).
•: ONO-5334 increased both trabecular and cortical bones.
•: ONO-5334 increased femoral neck bone strength.

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