A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy

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A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy

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作者：Kaori Hanaoka ; ^{kaori.hanaoka@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Yuka Kawato ^{yuka.kawato@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Kaori Kubo ^{kaori.kubo@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Tomonori Nakanishi ^{tnakanishi@cc.miyazaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Masashi Maeda ^{masashi.maeda@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Koji Nakamura ^{koji.nakamura@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Jun Hirose ^{jun.hirose@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Takahisa Noto ^{takahisa.noto@santen.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Hidehiko Fukahori ^{hidehiko.fukahori@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Akihiko Fujikawa ^{akihiko.fujikawa@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Sosuke Miyoshi ^{sosuke.miyoshi@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Shoji Takakura ^{shoji.takakura@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Tatsuaki Morokata ^{tatsuaki.morokata@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Yasuyuki Higashi ^{yasuyuki.higashi@astellas.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AMR ; antibody-mediated rejection ; AR ; acute rejection ; CKD ; chronic kidney disease ; CR ; chronic rejection ; DSA ; donor specific antibodies ; IF/TA ; interstitial fibrosis/tubular atrophy ; KIM-1 ; kidney injury molecule 1 ; MCP-1 ; macrophage chemotactic protein 1 ; MHC ; major histocompatibility complex ; MRI ; magnetic resonance imaging ; OPN ; osteopontin ; PTC ; peritubular capillaries ; TIMP-1 ; tissue inhibitor of metalloproteinase-1
刊名：Transplant Immunology
出版年：2016
出版时间：September 2016
年：2016
卷：38
期：Complete
页码：19-26
全文大小：1246 K

文摘

•: Rat chronic rejection model that mimics clinical settings using fully MHC-mismatched transplants.
•: Detection of IF/TA under immunosuppressive therapy.
•: IgG was deposited in the glomerulus and PTC in the allografts.