Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: Molecular partners that shape immune responses

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• 作者：Moniek H.J. Meevissen ; Maria Yazdanbakhsh ; Cornelis H. Hokke
• 关键词：Trematode ; Schistosoma mansoni ; Eggs ; C-Type lectins ; Glycosylation ; Immunomodulation
• 刊名：Experimental Parasitology
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：132
• 期：1
• 页码：14-21
• 全文大小：385 K

文摘

Schistosome eggs and egg-derived molecules are potent immunomodulatory agents. There is increasing evidence that the interplay between egg glycoproteins and host C-type lectins plays an important role in shaping immune responses during schistosomiasis. As most experiments in this field so far have been performed using complex protein/glycoprotein mixtures or synthetic model glycoconjugates, it is still largely unclear which individual moieties of schistosome eggs are immunologically active. In this review we will discuss molecular aspects of Schistosoma mansoni egg glycoproteins, their interactions with C-type lectins, and the relevance to schistosome egg immunobiology.