Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury

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Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury

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作者：Kai Wu^a ; ^b ; Kailiang Zhou^a ; ^b ; Yongli Wang^a ; ^b ; Yifei Zhou^a ; ^b ; Naifeng Tian^a ; ^b ; Yaosen Wu^a ; ^b ; Deheng Chen^a ; ^b ; Di Zhang^a ; ^b ; Xiangyang Wang^a ; ^b ; Huazi Xu^a ; ^b ; ^{spinexu@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaolei Zhang^a ; ^b ; ^{callmeroger@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Spinal cord injury ; Prolyl hydroxylase inhibitor ; HIF1α ; Apoptosis
刊名：Brain Research
出版年：2016
出版时间：1 February 2016
年：2016
卷：1632
期：Complete
页码：19-26
全文大小：2566 K

文摘

•: FG-4592 treatment stabilized HIF1α expression in PC12 cells and in spinal cord.
•: FG-4592 inhibited apoptosis and increased the survival of neuronal PC-12 cells.
•: FG-4592 increased the survival of neurons in spinal cord lesions.
•: HIF-1α blocker YC-1 partially abolished the protective effect of FG-4592.

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