Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway

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Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway

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作者：Feng-Tao Liu^a ; ^b ; ¹ ; ^{liuft110@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Yu-Jie Yang^a ; ^b ; ^c ; ¹ ; ^{yujieyang1015@me.com" class="auth_mail" title="E-mail the corresponding author} ; Jian-Jun Wu^a ; ^b ; ^{jungliw@126.com" class="auth_mail" title="E-mail the corresponding author} ; Shan Li^c ; ^{shanli1121@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yi-Lin Tang^a ; ^b ; ^{tangyilin10@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jue Zhao^a ; ^b ; ^{orangerange_zj@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Zhen-Yang Liu^a ; ^b ; ^{besuretowin@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bao-Guo Xiao^a ; ^b ; ^{bgxiao@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ji Zuo^c ; ^{jzuo@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wen Liu^c ; ^{liuwen@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jian Wang^a ; ^b ; ^{wangjian336@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：α-syn ; α-synuclein ; PD ; Parkinson׳s disease ; ROCK ; Rho kinase ; WT ; wild-type ; LBs ; Lewy bodies ; UPS ; ubiquitin proteasome system ; BSA ; bovine serum albumin ; CMA ; chaperone-mediated autophagy ; 3-MA ; 3-methyladenine ; Co-IP ; Co-Immunoprecipitation ; TEM ; Transmission Electron Microscope ; PI3K ; phosphoinositide 3-kinase ; JNK 1 ; c-Jun N-terminal kinase 1.
刊名：Brain Research
出版年：2016
出版时间：1 February 2016
年：2016
卷：1632
期：Complete
页码：9-18
全文大小：3111 K

文摘

•: A53T α-synuclein could decrease neurite outgrowth with enhanced Rho kinase activity.
•: Fasudil could attenuate the neurite outgrowth injury caused by A53T α-synuclein.
•: Fasudil could promote the autophagic degradation of A53T α-synuclein.
•: The effect of fasudil was mediated by JNK/Bcl-2/beclin 1/Vps34 pathway.