Impaired hippocampal synaptic plasticity and NR2A/2B expression ratio in remifentanil withdrawal rats

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Impaired hippocampal synaptic plasticity and NR2A/2B expression ratio in remifentanil withdrawal rats

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作者：Yi-yi Wang^a ; ^{wyiyi70@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shichang Liu^b ; Nan Zhang^c ; Jing Yang^d ; Yinguo Zhang^e
关键词：Remifentanil withdrawal ; Synaptic plasticity ; Open field test ; Morris water maze ; NR2A/NR2B ; mEPSCs
刊名：Neurotoxicology
出版年：2016
出版时间：March 2016
年：2016
卷：53
期：Complete
页码：115-123
全文大小：798 K

文摘

•: The remifentanil addiction and withdrawal rat model was established.
•: The remifentanil withdrawal rat exhibited damage of memory and synaptic plasticity.
•: Increased hippocampal NR2A/NR2B ratio may participate in the impairment of LTP.
•: The changes of basal synaptic transmission may participate in the impairment of LTP.

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