The P20R mutation of αB-crystallin diminishes its anti-apoptotic activity in human lens epithelial cells

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• 作者：Peiran Zhu¹ ; Weiwei Li¹ ; Mengxia Ni ; Cui Zhang ; Shuaimei Liu ; Qiuyue Wu ; Weijun Jiang ; Jing Zhang ; Mingchao Zhang ; Xiaojun Li ; Yingxia Cui ; Chunyan Xue ; Xinyi Xia ; ^{xiaxynju@163.com}
• 关键词：αB-crystallin ; Point mutation ; Anti-apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：463-467
• 全文大小：895 K
• 卷排序：483

文摘

We identified a novel mutation (P20R) in αB-crystallin. The mutation decreased anti-apoptotic activity in αB-crystallin, which compared with the native protein. We speculate that the mutation may influence phosphorylation, especially Ser19.