Vitamin D receptor is a novel transcriptional regulator for Axin1

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• 作者：Dapeng Jin^a ; Yong-guo Zhang^b ; Shaoping Wu^a ; Rong Lu^b ; Zhijie Lin^b ; Yuanyuan Zheng^a ; Honglei Chen^a ; Gabriella Cs-Szabo^a ; Jun Sun ; Ph.D. ; AGAF^a ; ^b ; ^{junsun7@uic.edu} ; ^{junsun7@gmail.com} (Associate Professor)
• 关键词：Axin1 ; Beta-catenin ; Vitamin D ; VDR ; VDR genomic binding site ; IBD ; Intestine ; Inflammation ; Transcriptional factor ; Wnt
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：430-437
• 全文大小：1675 K
• 卷排序：165

文摘

VDR deletion leads to lower protein and mRNA levels of Axin1. VDR regulation of Axin1 is through a VDR genomic binding site on the promoter region of Axin1. VDR is important for the maintenance of physiological levels of Axin1 in intestine. The discovery of Axin1 as a VDR target gene provides novel and fundamental insights into the interactions between the VDR and β-catenin signaling pathways.