Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

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• 作者：Oshima ; Yuichi ; Fujio ; Yasushi ; Funamoto ; Masanobu ; Negoro ; Shinji ; Izumi ; Masahiro ; Nakaoka ; Yoshikazu ; et. al.
• 关键词：Aldosterone ; Hypertrophy ; Remodeling ; Signal transduction ; Endothelin-1
• 刊名：FEBS Letters
• 出版年：2002
• 出版时间：July 31, 2002
• 年：2002
• 卷：524
• 期：1-3
• 页码：123-126
• 全文大小：182 K

文摘

Aldosterone is thought to regulate cardiac work independently of sodium retention, though the mechanisms remain to be known. In the present study, we have demonstrated that aldosterone reinforces endothelin-mediated cardiac hypertrophy with the increase in cell surface area and upregulation of the transcripts characteristic of hypertrophy. We have also shown that aldosterone augments c-Jun N-terminal kinase activation induced by endothelin-1. Taken together, it is suggested that aldosterone modulates cardiac hypertrophy, at least partially, synergistically with extracellular signals that have been shown to be involved in cardiac remodeling.