Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

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Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

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作者：Takuji Kawamura¹ ; Shigeru Miyagawa¹ ; Satsuki Fukushima¹ ; Akira Maeda² ; Noriyuki Kashiyama¹ ; Ai Kawamura¹ ; Kenji Miki³ ; Keisuke Okita³ ; Yoshinori Yoshida³ ; Takashi Shiina⁴ ; Kazumasa Ogasawara⁵ ; Shuji Miyagawa² ; Koichi Toda¹ ; Hiroomi Okuyama² ; Yoshiki Sawa¹ ; ^{sawa-p@surg1.med.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Stem Cell Reports
出版年：2016
出版时间：8 March 2016
年：2016
卷：6
期：3
页码：312-320
全文大小：3455 K

文摘

•: Cardiomyocytes from iPSCs can treat heart disease
•: iPSC-CMs were transplanted into MHC-matched or unmatched cynomolgus macacques
•: Matched iPSC-CM grafts had better survival and less host rejection immune response
•: Immunosuppression was still required for successful allogeneic iPSC-CM engraftment

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