Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia

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Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia

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作者：Inpyo Choi¹ ; ^{ipchoi@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author} ; Suk Ran Yoon¹ ; Soo-Yeon Park¹ ; Hanna Kim¹ ; Sol-Ji Jung¹ ; You-Lee Kang¹ ; Je-Hwan Lee² ; Jung-Hee Lee² ; Dae-Young Kim² ; Jae-Lyun Lee² ; Han-Seung Park² ; Eun-Ji Choi² ; Young-Shin Lee² ; Young-A. Kang² ; Mijin Jeon² ; Miee Seol² ; Seunghyun Baek² ; Sung-Cheol Yun³ ; Hwa Jung Kim³ ; Kyoo-Hyung Lee² ; ^{khlee2@amc.seoul.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Donor natural killer (NK) cell infusion ; HLA-haploidentical hematopoietic cell transplantation ; Acute myelogenous leukemia
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：November 2016
年：2016
卷：22
期：11
页码：2065-2076
全文大小：809 K

文摘

•: Early additional donor natural killer cell infusion after HLA-haploidentical hematopoietic cell transplantation is not associated with an enhanced antileukemia effect
•: Early donor natural killer cell infusion after HLA-haploidentical hematopoietic cell transplantation is associated with significant toxicities related to cytokine release
•: Higher NKp30 expression on donor natural killer cells is an independent predictor for higher complete remission and less leukemia progression after HLA-haploidentical hematopoietic cell transplantation and donor natural killer cell infusion