Screening active compounds from Corydalis yanhusuo by combining high expression VEGF receptor HEK293 cell membrane chromatography with HPLC - ESI - IT - TOF - MSn method

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• 作者：Fen Wei^a ; ^b ; Qi Hu^a ; ^b ; Jing Huang^a ; ^b ; Shengli Han^a ; ^b ; ^{slhan2008@mail.xjtu.edu.cn} ; Sicen Wang^a ; ^b
• 关键词：YuanHu ; Vascular endothelial growth factor receptor ; Cell membrane chromatography ; HPLC- ESI-IT-TOF-MSn
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：134-139
• 全文大小：1307 K
• 卷排序：136

文摘

CMC coupled with HPLC-IT-TOF-MS system was used to screen active components. Tetrahydropalmatine and corydaline were screened from YuanHu.. Sorafenib, tetrahydropalmatine and corydaline could inhibit the growth of VEGFR-2 cells.