Origin and evolution of LX4 genotype infectious bronchitis coronavirus in China

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• 作者：Wenjun Zhao¹ ; Mengying Gao¹ ; Qianqian Xu ; Yang Xu ; Yan Zhao ; Yuqiu Chen ; Tingting Zhang ; Qiuling Wang ; Zongxi Han ; Huixin Li ; Lingfeng Chen ; Shuling Liang ; Yuhao Shao ; Shengwang Liu ; ^{swliu@hvri.ac.cn}
• 关键词：Infectious bronchitis virus (IBV) ; LX4 genotype (QX-like) ; Evolution ; Topology ; Clade I ; Clade II
• 刊名：Veterinary Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：198
• 期：Complete
• 页码：9-16
• 全文大小：1176 K
• 卷排序：198

文摘

LX4 is one the most important genotypes of infectious bronchitis coronavirus worldwide. Two LX4 genotype viruses have novel genomic organizations which lacked 3a and 5b gene, respectively. Recombination events may be responsible for the emergence of the LX4 genotype. Most of these viruses disappeared likely because they were not “fit” to adaptation in chickens. The “fit” viruses continued to evolve and have become widespread and predominant in commercial poultry.