VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

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• 作者：Shih-Wei Lee^a ; ^b ; Tzu-Yi Chuang^a ; Hsiu-Han Huang^a ; Chi-Wei Liu^a ; Yung-Hsi Kao^b ; Lawrence Shih-Hsin Wu^c ; ^{lshwu@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：polymorphism ; tuberculosis ; VDBP ; VDR
• 刊名：Journal of Microbiology, Immunology and Infection
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：49
• 期：5
• 页码：783-787
• 全文大小：277 K

文摘

The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB.

Methods

We typed four VDR polymorphisms of restriction endonuclease sites for ApaI, TaqI, BsmI, and FokI and three VDBP polymorphisms—Thr420Lys, Asp416Glu, and Cys299Cys—in 198 patients with TB and 170 healthy volunteers.

Results

VDR TaqI, VDR BsmI, and VDBP Asp416Glu were significantly associated with TB susceptibility. Odd ratios of risk genotypes of the above three polymorphisms were 2.16 (95% confidence interval 1.01, 4.65), 2.14 (95% confidence interval 1.06, 4.31), and 2.24 (95% confidence interval 1.04, 4.80), respectively. VDBP haplotype analysis showed Gc1f carriers associated to TB.

Conclusion

The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.