Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats

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Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats

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作者：Yaning Liu^a ; Shangwu Wang^c ; Shijian Luo^a ; Zhendong Li^a ; ^{lizdsysu@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{ZDL809@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Fengyin Liang^b ; Yanan Zhu^c ; Zhong Pei^b ; ^{peizhong@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ruxun Huang^b
关键词：GDNF ; glial cell line-derived neurotrophic factor ; GFRα-1 ; GDNF-family receptorα-1 ; PTD ; protein transduction domain ; BBB ; blood&ndash ; brain barrier ; DG ; dentate gyrus ; SVZ ; subventricular zone ; MCAO ; middle cerebral artery occlusion ; CCA ; common carotid artery ; ICA ; internal carotid artery ; ECA ; external carotid artery ; PBS ; phosphate buffered saline ; BrdU ; 5-bromo-2deoxyuridine
刊名：Neuroscience Letters
出版年：2016
出版时间：23 March 2016
年：2016
卷：617
期：Complete
页码：150-155
全文大小：1690 K

文摘

•: PEP-1-GDNF is neuroprotective by intravenous administration.
•: PEP-1-GDNF reduces the infarct volume.
•: PEP-1-GDNF promotes the neurogenesis in the hippocampus.
•: PEP-1-GDNF improves the neurological function after stroke.

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