Preparation of 7-Arylmethyl-1H-pyrrolo[3,4-c]pyridine-1,3-(2H)-diones and α-aryl-3-hydroxy-5-pyridylacetonitriles using arynic methodology

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• 作者：Anlai ; Wang ; Tandel ; Sagun ; Hongming ; Zhang ; Yuwei ; Huang ; Holdeman ; Terra C. ; Biehl ; Edward R.
• 刊名：Tetrahedron
• 出版年：1998
• 出版时间：April 2, 1998
• 年：1998
• 卷：54
• 期：14
• 页码：3391-3400
• 全文大小：403 K

文摘

7-Arylmethyl-1H-pyrrolo[3,4-c]pyridine-1,3-(2H)-diones and α-aryl-3-hydroxy-5-pyridylacetonitriles can be prepared in modest yields from the respective reactions of 5-bromonicotinamide and 5-chloro-3-pyridinol with arylacetonitriles and LDA.