Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks

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• 作者：Ishizaki ; Takeshi ; Koizumi ; Tomonori ; Ruan ; Zonghai ; Wang ; Zhangang ; Chen ; Qiuhong ; Sakai ; Akio
• 关键词：High-altitude wild yak ; Pulmonary circulation ; NO inhibitor
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2005
• 出版时间：April 15, 2005
• 年：2005
• 卷：146
• 期：2-3
• 页码：225-230
• 全文大小：117 K

文摘

We studied the effect of N^w-nitro-l-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800m a.s.l. were used. After measuring control values, 20mg/kg of NLA was administered via the jugular vein to each animal, and pulmonary hemodynamics and blood gases were repeatedly measured at simulated altitudes of 0, 2260 and 4500m.