AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors

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• 作者：Brian Zingg¹ ; ² ; ⁶ ; Xiao-lin Chou¹ ; ² ; ⁶ ; Zheng-gang Zhang¹ ; ³ ; Lukas Mesik¹ ; ² ; Feixue Liang¹ ; ³ ; Huizhong Whit Tao¹ ; ⁴ ; ^htao@usc.edu ; Li I. Zhang¹ ; ⁵ ; ⁷ ; ^{liizhang@usc.edu}
• 关键词：transsynaptic/transneuronal tracer ; AAV serotypes ; mapping neural circuits ; corticofugal projection ; superior colliculus ; intersectional strategy ; defensive behavior ; flight and freezing ; Cre and Flp system
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：33-47
• 全文大小：7001 K
• 卷排序：93

文摘

AAV1 and AAV9 exhibit anterograde transsynaptic spread properties AAV1-Cre can transsynaptically tag input-defined postsynaptic neurons Corticocollicular input-defined SC neurons mediate different defense behaviors With an intersectional approach, the tagging can be postsynaptic cell-type specific