Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3

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• 作者：Nicolas Gutierrez-Castellanos¹ ; ² ; ³ ; Carla M. Da Silva-Matos¹ ; ² ; Kuikui Zhou³ ; Cathrin B. Canto² ; Maria C. Renner¹ ; Linda M.C. Koene¹ ; Ozgecan Ozyildirim² ; Rolf Sprengel⁴ ; Helmut W. Kessels¹ ; ⁵ ; ^{h.kessels@nin.knaw.nl} ; Chris I. De Zeeuw² ; ³
• 关键词：learning ; cerebellum ; Purkinje cell ; synapse ; LTP ; AMPA receptor ; GluA3 ; Epac
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：409-424
• 全文大小：6240 K
• 卷排序：93

文摘

Cerebellar learning depends on expression of GluA3, but not GluA1, in Purkinje cells GluA3 is required to induce LTP, but not LTD, at PF-PC synapses GluA3-dependent potentiation involves a cAMP-driven change in channel conductance GluA3-mediated LTP and learning are induced via cAMP-mediated Epac activation